Hot Melt Extrusion[HME] has emerged as a novel processing technology in developing molecular dispersions of Active Pharmaceutical Ingredients[APIs] into various polymer and lipid matrices. Currently, this technology is extensively used in pharmaceutical research and development for solubility enhancement, time controlled, modified, extended and targeted drug delivery.
STEER H.M.E.S is a complete system with its core unit â€˜Hot Melt Extruderâ€™ having the STEER EPZ products like screw elements & barrels. Appropriate with both up-stream and down-stream components like micro feeder, split and side feeder, refill silo and its associated platform, chill roll unit, chill air conveyor unit, pelletizer and flaker complete the system. The system is modular, comprehensive and scalable.
Pharmaceutical Compounding using Hot Melt Extrusion(HME) involves achieving a homogenous solid dispersion or solution by mixing and/or melting API with one or more excipients such as polymers, lipids, surfactants, diluents, lubricants, glidants, plasticizers and other modifiers for the purpose of stabilization, bioavailability enhancement, controlled release or taste masking and improved delivery especially in oral and trans-dermal systems.