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INTEGRAAL – THE CONTINUOUS GRANULATOR

A Paradigm Shift in Continuous Manufacturing in Pharma Industry

The pharma industry is moving rapidly towards continuous manufacturing to enjoy the benefits of quality by design and INTEGRAAL exactly meets this need. This compact, versatile and efficient equipment continuously produces granules with superior properties at the lowest cost and at scale.

The INTEGRAAL is a continuous granulating equipment - capable of producing superior property granules of several pharmaceutical drugs*. It effectively processes the APIs with excipients, binders employing spatial and temporal control in a continuous twin screw process that causes binding between particles, gradually agglomerating it into granules of superior properties on flowability, porosity, dispersibility. The technology consumes a fraction of the energy that is needed for a traditional batch process and can be employed for wet, melt and dry granulation.   
The technology is ideally suited for adoption by progressive pharma companies in both green field and brownfield projects. The technology can effectively replace tedious batch processes that suffers from huge analytics costs, batch rejection rates, quality control issues, huge energy consumption resulting in a low value for money.
* Examples:  Analgesics, Antidiabetic, Anti-inflammatory, Antimalarial, Hypolipidemic, Antidepressant drugs.
Various Models
INTEGRAAL comes in various models which allows you to customize based on your operational and manufacturing needs.
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Benefits
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Quality by Design

Ensures superior product quality without extensive testing thereby reducing analytical costs significantly.

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Enhanced Product Properties

Produces granules with superior properties, such as porosity, dispersibility, flowability.

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High Energy Efficiency – Leading to Low OPEX

Consumes a fraction of the energy required by traditional batch processes, contributing to lower operational costs and a reduced carbon footprint.

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Processing Time Reduction

Processes materials in minutes, compared to several hours in traditional batch processes.

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Online Quality Control

Enables real-time monitoring and adjustment, ensuring high-quality output continuously thereby eliminating batch rejections.

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Formulation Agnostic Technology

Compatible with a wide range of formulations, providing flexibility in production.

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Efficient Unit Operations

Requires only 2-3 unit operations versus 7-10 in batch processes, reducing complexity.

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Versatility

One equipment for dry, wet, and moisture-activated granulation, providing highest flexibility with quicker transition times.

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Compact Footprint

Occupies only 25% of the space required by batch processes, optimizing facility usage.

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Environmental Friendliness

Operates as a green technology with significantly lower environmental impact compared to polluting batch processes.

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